Fatal familial insomnia. Italian man, who died in Venice in the year 1765. Increasing insomnia. Panic attacks. Paranoia. Phobias. Hallucinations. Complete inability to sleep. Rapid loss of weight. Dementia. Death. Mild atrophy of frontal cortex. Moderate atrophy of thalamus. Mutation at codon 178 of the prion protein gene. Sleeping drugs not helpful. Worsening of clinical manifestations. Mouse model for FFI in the late 2000s. ‘Sleepless’, novel by Charlie Huston (2010), disease has killed ten-percent of worlds population.

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